SYNVISC Description: This medicine is a viscosupplement used to treat the pain of osteoarthritis of the knee. Synvisc (Hylan G-F 20) is an FDA-approved therapy that provides lubrication for your knee. It is a viscosupplement used to treat the pain of osteoarthritis of the knee. It also acts as a "shock absorber" to cushion your knee joint. Synvisc® is an elastic and viscous fluid that is made from a substance called hyaluronan that is found in normal joint fluid. Hyaluronan acts as a "shock absorber" and lubricant in your knee joint and is needed for your joint to work properly. Ingredients: HYLAN G-F 20 (HIGH-lan) Directions: Follow the directions for using this medicine provided by your doctor. This medicine is usually administered as an injection at your doctor's office, hospital, or clinic. This medicine comes with a patient information leaflet. Read it carefully. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. STORE THIS MEDICINE below 86 degrees F (30 degrees C) in the original packaging, away from light. DO NOT FREEZE. Do not miss your doctor appointments while taking this medicine. If you must miss an appointment, notify your doctor as soon as possible. Cautions: IT MAY TAKE SEVERAL INJECTIONS for this medicine to work fully. Complete the full treatment course, even if you are already feeling better. KEEP ALL DOCTOR APPOINTMENTS while you are using this medicine. AVOID USING certain skin disinfectants (containing ammonium salts). FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. IT IS UNKNOWN IF THIS MEDICINE IS EXCRETED in breast milk. IF YOU ARE OR WILL BE BREAST-FEEDING while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby. |
Knee-Osteoarthritis-Pain.com |
NEOVISC What Is Hyaluronate? Hyaluronate is a naturally occurring polysaccharide found in connective tissue, synovial fluid, vitreous humour of the eye, birth canal etc. It has been shown to play an important role in many biological processes such as embryonic development, cell differentiation, tissue hydration and proteoglycan organization. In the joint Hyaluronate provides the viscoelasticity (lubrication) of synovial fluid and the resilience and elastic strength (cushioning effect) to cartilage. NeoVisc is a 1.0% solution of highly purified Sodium Hyaluronate, which has been clinically available in Canada since 1997. How Does NeoVisc Work? Patients with Osteoarthritis (OA) typically experience pain and loss of mobility because of changes to the internal environment of the affected joint. NeoVisc® works as a viscosupplement by improving the natural viscosity and elasticity of synovial fluid, thereby increasing lubrication, improved joint mobility and a reduction of pain. To oversimplify, think of an intra-articular injection of NeoVisc® as putting oil on a rusty hinge. |
HYALGAN Hyaluronic acid sodium salt INDICATION Hyalgan is indicated for the sustained relief of pain and joint dysfunction in osteoarthritis of the knee, shoulder and hip. DIRECTIONS FOR USE: Hyalgan 20 mg/2 ml is administered by intra-articular injection once a week, for a total of 3 - 5 injections, using standard technique. DESCRIPTION: Hyalga is a sterile, non-pyrogenic, viscous, aqueous buffered solution of a defined high molecular weight (500,000 - 730,000 Da) fraction (Hyalectin™) of highly purified hyaluronic acid salt that is extracted from rooster combs. Hyaluronic acid, a natural polymer of the glucosaminoglycan family, is a long, straight chain polysaccharide consisting of N-acetyl glucosamine and glucuronic acid in alternation as disaccharides. Hyalgan® consists of 2 ml of a 10 mg/ml solution of hyaluronic acid in buffered physiological sodium chloride, pH 6.8-7.5. CONTRAINDICATIONS: do not administer to patients with known hypersensitivity to any ingredient of the product or to avian proteins. do not administer to patients with known hypersensitivity to any ingredient of the product or to avian proteins. Intra-articular injections are contraindicated in cases of infections or skin diseases in the area of theinjection site. at present, there are no other known contraindications to the intra-articular administration of Hyalgan®. PRECAUTIONS: Procedures to maintain the sterility of the injection site and use of proper technique for injection must be followed. Do not use Hyalgan® if package is opened or damaged. Store in original packaging (protected from light) below 25ºC (at room temperature). DO NOT FREEZE. although animal studies with Hyalgan® that evaluated its potential reproductive and developmental toxicity were negative, Hyalgan® has not been tested in pregnant women or children under 18 years of age. As with any invasive joint procedure, it is recommended that care be taken not to overburden the joint immediately following the intra-articular injection and that the procedure not be performed if the patient does not have access to medical attention for the subsequent 48 hours. WARNINGS: Hyalgan® is only for intra-articular use. Remove joint effusion, if present, before injecting Hyalgan®. do not concomitantly use disinfectants containing quaternary ammonium salts because hyaluronic acid can precipitate in their presence. STERILE CONTENTS. The syringe is intended for single use. Discard any unused Hyalgan®. HOW SUPPLIED: Hyalgan® is supplied in 2 ml pre-filled syringes. Each syringe contains: Hyaluronic acid sodium salt 20.0 mg Sodium chloride 17.0 mg Monobasic sodium phosphate • 2H2O 0.1 mg Dibasic sodium phosphate • 12H2O 1.2 mg Water for injection q.s. to 2.0 ml |
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